BIOL 3P30 Lecture Notes - Lecture 30: Oxidative Stress, Intron, Protein Folding
22 Aug 2015
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Hsc70 is always expressed but can be upreguglated during heat shock. Families have nothing to do with one another. Hsp70 family has no introns- skip the splicing because splicing can be inhibited during heat shock. Lack of active hsp70 (because of inactivation by antibody) cell sensitivity to temperature. Animals that cannot (or do not) induce hsp transcription do not survive thermal transitions. The one that lives intertidially make the hsp70. In addition to heat, hsps expressed in response to: Different depending on the family of proteins we are talking about. The individual hsp families are quite different in structure and function, each with unique activities, but all help to: Some are always present because under normal conditions you can still get misfolding of proteins. Pull apart proteins before imported into the mitochondria. Grab on to the protein through a clamp of the mechanism (atp consuming reaction)
