HLSC 3P93 Lecture Notes - Lecture 3: Ketone Bodies, Chemokine, Oxidative Stress
11 Feb 2014
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Document Summary
Disease stress injury altered health. Adaptation altered structure or change in a steady state. Dose intensity duration and severity pf cellular exposure to stress: ex/interruption of coronary blood supply <1-2mins is reversible repaired. Cell vulnerability: inherent vulnerability of cells to a given stress, more specialized cells are more vulnerable, ex/skeletal muscles can tolerate interrupted blood flow longer than the cardiac muscle. Vulnerable targets of injury: cell membrane, energy metabolism, protein synthesis, genes, because most are interconnected injury to one will affect others. Disease producing cellular injury and stress: hypoxia cvd, anemia, respiratory disease, chemical alcohol, diabetes, infection hiv, immune reactions autoimmune, nutritional imbalance obesity, iron-deficiency, genetic derangements cancer, crohns disease. Necrosis: cell homicide due to pathological stimuli, injures surrounding tissue. Apoptosis: cell is sacrificed to avoid damage to the surrounding cells. Network of cells and tissues: lymphocytes wbc, lymphoid tissue thymus, bone marrow, lymphatic disposal spleen, tonsils, adenoids, lymph nodes.
