HLSC 3P97 Lecture Notes - Lecture 10: Interleukin 10, Integrase, Reverse Transcriptase
15 Dec 2017
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Document Summary
Major envelope protein called gp120 on hiv virus. This is the ligan/cd4 receptor (gp120) on t-cells and macrophages. Co receptors that come into proximity when hiv binds to the cell. These co receptors get recruited into the process of getting the virus inside the cell. If co-receptor isn"t functioning, it can bind, but virus cant get in. Hiv bears gp120 and finds the stock of cd4, and then pulls the co-receptor towards itself (cxcr4/ccr5) Once there is a co-receptor interaction, hiv will get into the cell and go through the replication process. Ccr5 expression is increased when someone has m. tb, lps and a th2 cytokine called. Il-10 is a down regulating cytokine in the th1 cells. Higher the expression of the co-receptors, the higher the expression. Downregulate co receptors = hiv cannot get into the cells. Cxcr4 is also a co-receptor (chemokine) this binds hiv and then cd4 antigen is bound, then chemokine co-receptor is bound.
