HLSC 3P97 Lecture Notes - Lecture 4: Adaptive Immune System, Pattern Recognition Receptor, Innate Immune System
13 Feb 2018
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Document Summary
Not fussy, it"ll clean up anything and everything with the same mop and bucket. Innate immunity can be seen as a mop and bucket. Adaptive immunity - it"s gotta fit like a glove . Antigen non-specific (same receptors for multiple pathogens, attacks anything non-self) Antigen-specific (b and t cells have receptors that only see one antigen) Highly repetitive patterns in microbes that the innate immune system recognizes. Larger the structure, the more likely the immune system is to recognize it. *innate immune system is looking for a general area of foreigness. Adaptive immune system lymphocytes have highly specific receptors. Binding of lps or lipoproteins triggers intracellular signals in the cytoplasm and just outside the cell membrane that lead to transcription factors. Nfk-b - transcription factor that works in many cells - turns on inflammatory cytokines. Type 1 interferon (irf3), which downregulates the replication of viruses. When these are made, the bacteria target their activity against tlrs.
