HLSC 1F90 Lecture Notes - Lecture 4: Adaptive Immune System, Natural Killer Cell, Testicular Cancer
18 Oct 2017
School
Department
Course
Professor
Document Summary
Rare rare: 1% of all male cancers. Most common cancer in men 15-35 years of age. Us incidence = 8500 cases/year; 1/250 men. Us mortality = 350 deaths/years; 1/5000 men with early detection. Survival dependent on stage at diagnosis: early: ~100% survival with treatment, late: 75% survival with treatment. The immune system can distinguish self from non-self. Primary lymphoid organs: where the cells are born, thymus, bone marrow. Secondary lymphoid organs: where the cells work, spleen, lymph nodes, tonsils & adenoids. Because we are co-evolved with microbes and had to survive them. Protection again disease at every level: skin, mucous membranes, cells portable organs of defense, cytokines intercellular communication proteins. Innate immunity: not specific to any one organism, uses the same cells to recognize, bind and respond to all non-self molecules, (cid:498)primes(cid:499) the adaptive immune system, adaptive immunity, specific for individual organisms/antigens. The two arms of immunity share some resources but not others. Mucous membranes: alimentary tract, respiratory tract.
