HLSC 2P27 Lecture Notes - Lecture 7: Confounding, Belatacept, Tamoxifen
6 Feb 2018
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Rct is at the top, with community trial. Cannot be done when we know that the intervention can be harmful. Rct is a quantitative interventional trial in which the efficacy and safety of treatment is evaluated in groups of subjects followed prospectively. If we randomize patients without looking at their profiles, we eliminate the confounding variables. Rct is trying to see if the experimental therapy is better (most of the time) Simple: assign patients a number and put them into either study or control group. Most frequently used, but does not guarantee balance in numbers in trial. Block: divide patients into blocks based on selected baseline characteristic; number in each block = 2x number of treatment groups; randomize subjects in each block to treatment. Stratified: group patients by important clinical demographic features first (ex. Take out people who have characteristics that we believe will affect the outcome.
