KINE 2P20 Lecture Notes - Lecture 15: Low-Density Lipoprotein, Apoptosis, Subcutaneous Tissue
9 May 2018
School
Department
Course
Professor
Nutrition 2P20
Surgical Treatments for Obesity
Obalon Balloon System
- 6-month, swallowable intrgastric balloon system indicated for temporary us =e to
facilitate weight loss in adults with obesity who have failed to lose weight through diet
and exercise
Bariatric Surgery
- causes weight loss because it alters GI tract
▪ reduce food intake
▪ reduce nutrient absorption
Gastric Banding (Gastroplasty)
- affects stomach size
▪ adjustable band
- slows rate at which food leaves stomach
- restricts food intake
Gastric Bypass
- bypass part of stomach and SI
▪ connects SI to upper part of stomach
- small stomach limits intake
- shorter SI limits absorption
Liposuction
- vacuuming out the subcutaneous fat with a hollow needle
- primarily cosmetic
- does not decrease disease risk
Weight Loss Strategies
- reasonable goals and moderate losses (~10% initial weight in 6 months)
- focus on losing fat mass and not muscle/bone
- maintain metabolic rate
Insulin resistance – the inability to use glucose for fuel in muscle
- increase uptake and usage of FFAs with elevated blood glucose
- rely on contraction sensitive GLUT4 transporters instead
▪ importance of exercise in glucose control
Obesity and Type 2 Diabetes
- Obesity = more adipocytes = more TG/FFA (fat)
▪ Lipotoxicity (damage to tissues)
find more resources at oneclass.com
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Document Summary
6-month, swallowable intrgastric balloon system indicated for temporary us =e to facilitate weight loss in adults with obesity who have failed to lose weight through diet and exercise. Bariatric surgery causes weight loss because it alters gi tract reduce food intake reduce nutrient absorption. Affects stomach size: adjustable band slows rate at which food leaves stomach restricts food intake. Bypass part of stomach and si: connects si to upper part of stomach small stomach limits intake shorter si limits absorption. Liposuction vacuuming out the subcutaneous fat with a hollow needle. Weight loss strategies reasonable goals and moderate losses (~10% initial weight in 6 months) focus on losing fat mass and not muscle/bone. Insulin resistance the inability to use glucose for fuel in muscle increase uptake and usage of ffas with elevated blood glucose rely on contraction sensitive glut4 transporters instead importance of exercise in glucose control. Obesity = more adipocytes = more tg/ffa (fat: lipotoxicity (damage to tissues)
