SCIE 1P51 Lecture Notes - Lecture 22: Angiogenesis, Sunburn, Zinc Oxide
16 Sep 2016
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Cancer (restrict angiogenesis: shut down the growing veins of cancerous tumors. We worry about the uva which is responsible for development of a slow and natural tan. Part of the spectrum gives sunburns as well a vitamin d. it produces new pigment formation, sunburn, vit. *ozone layer = a lot of chemicals we are putting out are destroying. Sunblock: reflect radiation, radiation comes onto the chemical and goes back into the atmosphere. Active ingredients physical agents: zinc oxide = 250-400nm; covering the whole uva/uvb spectrum, titanium dioxide = 260-360nm. Active ingreidents uvb: cinnamates = 280-320nm, salicylates = 260-320nm, paba = 260-313nm. Active ingreidents uva: benzophenones = 260-360nm, dibenzoylmethanes = (parasol) 320-400nm. Skin type i always burns easily; never tans (1) Skin type ii always burns easily; tans minimally (2) Skin type vi never burns; deeply pigmented (6) Water/sweat/perspiration resistant = 20 minutes very water/sweat/perspiration resistant = 40 minutes. Testing protocols: hairless mice, solar simulator, human subjects, skin type i/ii.
