MICI 2100 Lecture 15: MICI 2100 Lecture 15
2 Nov 2018
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Mici 2100 lecture 15 october 25, 2018 viral genomes i virus genomes and cellular antiviral. These viruses, even though might not cause disease in people with strong immune system, it might infect those with a weaker one. What virus fuses at the plasma membrane: influenza virus (fuses in the endocytic vesicles, hiv (fuses its envelope at the plasma membrane) ****, ebola (fuses in the endocytic vesicles, adenovirus (fuses in the endocytic vesicles) The native virus has spike proteins that are composed of gp41 (spans the viral envelope) and gp120 (has, at the end, variable loops). These variable loops are the binding site for cell surface receptors. At the bottom, there is the plasma membrane. At the top, the small membrane is the viral membrane. gp120 binds to cd4 and undergo the first host receptor interaction. This allows conformational change, resulting in the binding of the variable loops to the co-receptors, which is the chemokine receptors.
