MICI 3119 Lecture Notes - Lecture 30: Secretion, Pertussis, Type Ix Submarine
22 Dec 2019
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Mici 3119 lecture 30 november 25, 2019 bacterial protein secretion ii. Outline: type v secretion, type vi secretion (type vii and viii secretion) Iga protease of neiserria gornorrhoeae: pertactin of bordetella pertussis, pertactin is an important virulence factor for b. pertussis. It helps b. pertussis to attach to ciliated tracheal cells and is one of the components in licensed pertussis vaccines. Type v secretion system are called autotransporters, which are transported by the. The proteins in this secretion system have a n-terminal sequence that is going to direct them to the sec machinery and cleaved by protease once the protein reaches the periplasm. The bam complex and the chaperone help the protein fold, which forms a -barrel domain, linker domain and a passenger domain. The passenger domain travels through the pore and in some cases, the protein will stay and become a transmembrane protein. The bam complex also help with protein folding.
