NESC 3227 Lecture Notes - Parahippocampal Gyrus, Basal Ganglia, Temporal Lobe

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Published on 17 Apr 2013
School
Dalhousie University
Department
Neuroscience
Course
NESC 3227
Professor
February 5th, 2013
February-05-13
1:04 PM
H.M
Had both temporal lobes removed in order to control his epileptic seizures
Couldn't be controlled by nearly lethal doses of anti-epileptic drugs
Had anterograde amnesia as a result, as well as retrograde amnesia
o Retrograde memories were preserved up until a certain time, but most of them had
disappeared
So had global amnesia
Still had some of his temporal lobe remaining after the surgery
o The important bits that were involved in memory and emotional processing had been
removed
H.M.s memory
The only person he can remember is his neurologist
o Because he had very long history with him
o Couldn't remember anyone else
Can't learn a maze learning task
o Can't even remember trying to learn this from the day before
Spared functions in H.M.
His intelligence
o IQ of 117
Language ability didn't seem to be impaired
Spatial analysis
Memory was spared on some tasks
o Span of attention, looking online, finding a phone number, remembering it, then dialing it.
Or a block tapping span
As long as he uses rehearsal, he's able to keep it in mind
o Procedural learning, such as the mirror drawing task
Shows normal improvement in this task, but he never remembers having done this
before
Probably because his basal ganglia is still in tact
Unilateral temporal lobectomy
Treatment for epilepsy
Selective amygdalohippocampectomy is now performed instead because it removes a smaller
brain region (SAH)
Usually produce milder more material specific memory loss then do bilateral lesions
Effects of unilateral temporal lobectomy on memory
Removal of the left usually has an effect on verbal memory
Removal of right usually impairs non-verbal learning
o Delayed reproduction of the image copying task, like what we did in class
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Document Summary

Had both temporal lobes removed in order to control his epileptic seizures. Couldn"t be controlled by nearly lethal doses of anti-epileptic drugs. Had anterograde amnesia as a result, as well as retrograde amnesia: retrograde memories were preserved up until a certain time, but most of them had disappeared. Still had some of his temporal lobe remaining after the surgery: the important bits that were involved in memory and emotional processing had been removed. The only person he can remember is his neurologist: because he had very long history with him, couldn"t remember anyone else. Can"t learn a maze learning task: can"t even remember trying to learn this from the day before. Memory was spared on some tasks: span of attention, looking online, finding a phone number, remembering it, then dialing it. As long as he uses rehearsal, he"s able to keep it in mind: procedural learning, such as the mirror drawing task.

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