NESC 3227 Lecture Notes - Putamen, Hash Oil, Opiate

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Published on 17 Apr 2013
School
Dalhousie University
Department
Neuroscience
Course
NESC 3227
Professor
February 19th, 2013
February-19-13
2:31 PM
Cannabis
Most commonly used intoxicating substance over alcohol in some parts of the world (middle
eastern countries)
It has had a gradual shift in public perception of the years
o Turns you into homicidal maniac in the 50s & 60s
Use in states has been decriminalized
In the Netherlands, making it more difficult for non-dutch individuals to buy and use it in the cafes
Cannabis sativa
Two phenotypes
o One is not used for its active drug purposes, used for the manufacturing of fiber (hemp),
doesn't have psychoactive properties
o The other is used recreationally
o Male and female plants in both subtypes, female more cherished because it produces more
potent psychoactive effects
Pollination of female plant reduces psychoactive properties
So female plants are often isolated to avoid pollination
Forms of cannabis
Potency of marijuana usually measured in psychoactive effects, sometimes for medicinal value
o Content of THC (ratio of THC to other constituents) and potency of drug usually related
Marijuana
o Most common preparation
o Smoking leaves and flowers, or baked into brownies
o When you burn marijuana, you create new chemically active constituents
o When you ingest it orally, you create different metabolites through the process of
metabolism
So different effects produced from different administration methods
o Potency has increased over time, has to do with people genetically engineering it for greater
potency
Hashish
Hash oil
The cannabinoids
Active ingredient
o THC - delta9 tetrahydrocannabinol
A number of different cannabinoids exist in cannabis and may contribute to its effects
Delta 8
o Cannabinol
But wait
o Active ingredients depend upon preparation and route of administration
o When cannabinodiol burned is converted into delta9
o New cannabinoids are created during digestion & metabolism
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Document Summary

Most commonly used intoxicating substance over alcohol in some parts of the world (middle eastern countries) It has had a gradual shift in public perception of the years: turns you into homicidal maniac in the 50s & 60s. In the netherlands, making it more difficult for non-dutch individuals to buy and use it in the cafes. Pollination of female plant reduces psychoactive properties. So female plants are often isolated to avoid pollination. Potency of marijuana usually measured in psychoactive effects, sometimes for medicinal value: content of thc (ratio of thc to other constituents) and potency of drug usually related. Marijuana: most common preparation, smoking leaves and flowers, or baked into brownies, when you burn marijuana, you create new chemically active constituents, when you ingest it orally, you create different metabolites through the process of metabolism. So different effects produced from different administration methods: potency has increased over time, has to do with people genetically engineering it for greater potency.

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