NESC 3227 Lecture Notes - Motor Skill, Optic Radiation, Internal Jugular Vein

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Published on 17 Apr 2013
Dalhousie University
NESC 3227
March 26th, 2013
1:08 PM
Neurogenesis in adults: hippocampus and olfactory bulbs
Granule cells within hippocampus lead to increase in number of neurons within the hippocampus
Know table 25.1
Neural transplantation research
Parkinson's disease
o Rigidity, akinesia, tremor, posture/balance, slowness of movement
o Have initiation problems in cognition, in motor problems can't get started
Parkinson's disease
Loss of cells in the substantia nigra of the ventral midbrain
o Loss of motor function through dopaminergic innervations of basal ganglia and forebrain
Often treated with L-dopa
o Does reduce symptoms for many people
o Becomes ineffective over time though
o But have dyskinesias as side effects (movement abnormalities)
Early outcome of neuro-transplantation" fetal stem cells for parkinson's disease
Aborted fetal stem cells are injected into the putamen
Many patients improved as a result of this
Problem was that almost 50% of the people who received this treatment had developed
dyskinesias within two years of treatment
Injects stem cells into putamen and substantia nigra
The placebo effects are quite high in these studies (25%)
Are interventionists making a difference in recovery
Occupational therapy is very important and enhances recovery to a great extent
o OT services interventions reduced odds of poor outcome
o And increased personal activity of daily living scores
Individual rehabilitation after stroke
o Get function back to premorbid, healthier state
o Learn coping skills to get around deficit
o Works better than drills for attention, memory and other cognitive deficits
Visual field defects due to striate cortex or optic radiation lesions
People with these visual field defects often reported problems in everyday life, slowed reading
o Don't see things fast enough
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