BIOL 200 Lecture Notes - Lecture 48: Helicase, Phosphodiester Bond, Gonad
Document Summary
(cid:120) gcn4 has dna binding domain specific for an upstream sequence and there is a clear dna-protein interaction that takes place (cid:120) Dna-binding associating factors that will enhance transcription (cid:120) i. e. gcn4p and gcn5p, cbp, p300. It may represent dna that is unwound to provide a transcriptional template pores (cid:120) t(cid:396)a(cid:374)s(cid:272)(cid:396)iptio(cid:374)ally i(cid:374)a(cid:272)ti(cid:448)e (cid:396)egio(cid:374)s of the ge(cid:374)o(cid:373)e a(cid:396)e (cid:373)ai(cid:374)tai(cid:374)ed i(cid:374) a (cid:862)hete(cid:396)o(cid:272)h(cid:396)o(cid:373)ati(cid:374)ized(cid:863) state. Thei(cid:396) transcription could be detrimental to the cell/organism. Antibodies against modified histone tails can be used for chromatin. Dosage compensation (cid:120) females must inactivate one x chromosome early during embryonic development (random). Inactive x chromosomes are referred to as barr. Xist is a sexist gene product (cid:120) the xist locus encodes long non-coding rna (cid:120) It binds to discrete regions of the x chromosome and spreads along the x to eventually x-tinguish gene expression (cid:120) although many mechanisms have been proposed it is still not clear how this.
