BIOL 201 Lecture Notes - Lecture 13: Filamin, Fimbrin, Leading Edge
20 Feb 2018
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Document Summary
Orientation: actin in the leading edge of the cell is branched, actin polymerises in 3 steps. Last class, we started talking about actin filaments cytoskeleton: long polymers of actin monomer used by cells to construct a proportion of their, forms different structures based on location, cells control. Treadmilling due to equal polymerization at plus end and depolarization at minus end. Actin regulators allow cells to build divers and dynamic actin networks. 5 classes of actin filaments: formins, cophilins. Regulate the rate of growth of the actin filament. Caps actin filaments to prevent growth: capping protein, arp2/3 complex, acting crosslinkers. Form parallel or antiparallel arrays of actin filaments with the same spacing. Found in microvilli, filopodia, etc: fimbrin has the acting binding domains on the same polypeptide chains, -actinin needs to dimerize because it only have 1 binding domain, spectrin is a tetramer. Made of an - chain which homodimerizes with another - chain.
