BIOL 201 Lecture Notes - Lecture 12: Escherichia Coli, Filamin, Fimbrin
19 Apr 2018
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Document Summary
Actin filaments are arranged differently at distinct intracellular locations. Cells control the length, number, angle, bundling, and orientation of actin filaments. Actin treadmills at steady state due to equal loss of one negative end as gain of one positive end. Actin regulators allow cells to build diverse and dynamic networks. Can accelerate it or slow it down despite what the concentration of the solution would allow. Capping the end of the filament to prevent it from continuing to grow. Is the leading edge of a moving cell. Is full of cross-linked actin that is polymerizing out, but the thickness of the band stays the same as a function of time. Something is maintaining a steady concentration of actin near the leading edge. While new actin filaments are pushing out the plasma membrane, there is something at the back that is tearing the filaments apart such that they maintain steady state.
