BIOL 201 Lecture Notes - Lecture 31: Cell Adhesion Molecule, Cell Adhesion, Cadherin
27 Nov 2015
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Document Summary
Cells interact with and receive signals from their environment. Cells are making physical connections with their environment. Cells also receive chemical signals from their environment. Cells stick to each other and to their surroundings. Cell-cell contacts - through tight/gap junctions: mediated by cell adhesion molecules (cam) Cells make contact to the basal lamina through cell adhesion molecules. Cells express a wide, diverse range of cell adhesion molecules (cams) Cadherins, connexins, innexins, pannexins, claudin, integrins, ncams, jams, selectins. Categories have alpha and beta chains - a huge diversification. Cell-cell adhesion is strengthened by adding up many weak interactions. Can interact in cis (laterally) or trans (to other cells) Cells can have one strong contact or many strong contacts that add up. Cell-cell adhesion will sort out cells of different types into clusters. By h. v. wilson: ground up cells rearranged into clusters. Mixing two different types of cells together creates separate clusters: cells only bind to their own type.
