BIOL 201 Lecture Notes - Lecture 29: G1 Phase, S Phase, Mitosis
27 Nov 2015
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Cell enters g1 phase with one copy of the chromosomes. Cell undergoes a phase of dna synthesis (s phase) Second period of growth (g2) with duplicated dna. Enters m phase (mitosis) giving rise to daughter cells. There are two central requirements for cell division. A specific phase of dna replication was discovered by a mcgill graduate. Alma howard was working with a fava bean plant. Took root cells and incubated them with radioactive nucleotides. Found out that dna synthesis happened all at once. Cannot measure lengths, volumes, sizes, time, etc. Cell has a bunch of proteins, some are phosphorylated. A low concentration of kinase would yield a low amount of phosphorylated kinase. A higher concentration of kinase will cause an increase in phosphorylation. Being able to measure concentration allows cell to be able to measure time. Concentration comes from accumulation, and accumulation comes from time. One band on an sds page gel was accumulating and degrading - cyclin band.
