BIOL 202 Lecture Notes - Lecture 10: Chromosome, Transcription Factor Ii D, Mitosis
Document Summary
Review: chapter 8, p301-307 + chapter 12 p431-436 + 442-450. New: chapter 12 p436-440 + 450-453 + 456-462. Transcriptional control in eukaryotes: general, common and specific tfs, proximal promoter, enhancers and silencers. Transcriptional regulation via chromatin organisation: chromatin remodelling, histone acetylation and methylation the histone code, cytosine methylation. Epigenetic gene regulation: position effect variegation/genomic imprinting. **quiz #2 opens on thursday and will include material from lectures 7, 9, 10 and others from dr. dankort"s section last week (4+4qs) Transcriptional regulation is more complex in eukaryotes. Recall that in prokaryotes, rna pol can easily bind and start transcribing genes bc the dna is naked default state for gene expression will be on in the absence of input. In eukaryotes, it is a far more complex a process therefore in the absence of input, gene expression is off . Is a common point of control for differential regulation of gene expression between cell types.
