BIOL 300 Lecture Notes - Lecture 28: Calcium Signaling, Diglyceride, Gtpase

• School: McGill University
• Department: Biology
• Course: BIOL 300
• Professor: Frieder Schoeck

Document Summary

Gpcrs that regulate ion channels: they can either be regulated directly by a neurotransmitter (like serotonin) that binds directly to ion channels (ligand-gated ion channels, or it can bind indirectly through g protein coupled receptor. However in cardiac muscle cells, acetylcholine binds to the gpcr: in this pathway, when the g-alpha subunit gets activated, it"s actually the. This was sufficient to open the ion channel. G-protein activates phosphodiesterase) which cleaves cgnp: cgnp will bind to the ion channel, opening it, eventually the concentration of cgnp gets lower and lower, closing the ion channel, g protein is a gtpase. There are primary g proteins and then other gtpases like the rap gtpases: what distinguishes those is that the g-proteins hydrolyze gtp very quickly (don"t need the gap protein) In the vision pathway, you still need a gap protein to shut down the pathway even faster.