BIOL 300 Lecture Notes - Lecture 32: Alanine, Zygosity, Affinity Chromatography
5 Mar 2018
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Document Summary
In the wild type embryo you can see the blood in the heart area. Shp1 phosphatase can still bind to some receptors but can"t on another receptors his pathway could not be down regulated properly had more red blood cells than other people. Tgf- /bmp receptor, a receptor serine/threonine kinase: up to know we have been talking about tyrosine kinases but here it"s serine and threonine that get phosphorylated, you have a ligand called tgf that is always a dimer. Ri receptor: r-smad3 gets phosphorylated by the ri receptor which allows it to eventually go to the nucleus. Cells have to respond to a combination of signals: the cells receives constantly many signals, you need minimal signals for a cell to survive (growth factor signals). Without any signal, the cell will die: when they receive some more signals (proliferation or cell division), they will divide.
