PHGY 209 Lecture Notes - Lecture 7: Transferrin, Jaundice, Bilirubin
14 Oct 2017
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Erythropoiesis: (2-3 x 106/sec) (review above site of hematopoiesis) Yolk sac (cid:314) liver & spleen (cid:314) bone marrow (cid:314)axial skeleton. Pluripotent hematopoietic stem cell (cid:314) lymphoid stem cell (cid:314) lymphocyte (cid:314) myeloid stem cell (cid:314) erythrocyte/ ~ injection of bone marrow stem cells can reconstitute all hematopoietic cell types ~ The cytokine (erythropoietin) stimulates the committed stem cells (not the inducer for. Division and differentiation occurs over a period of 3 5 days. The red blood cells are then released into the blood stream and enters the circulation. These newly released blood cells (reticulocyte) are recognized as slightly immature for the first 24 hours after being released. Red cell precursors differentiation: decrease in size. Stem cell (18m) (cid:314) erythrocyte (7m: loss of nucleus, accumulation of hb. Reticulocytes: newly released red blood cell; has network inside the cell consists of the leftover ribosomal material (capable of synthesizing some hemoglobin) however after maturation (24 hours) it can no longer synthesize.
