BIOL 303 Lecture Notes - Lecture 14: Bone Morphogenetic Protein, Intermediate Mesoderm, Bone Morphogenetic Protein 4

• School: McGill University
• Department: Biology
• Course: BIOL 303
• Professor: Shelton Hendricks

Document Summary

Is established right at fertilization, when egg undergoes cortical rotation , allows d1 (dorso vegetal cell) to induce dorsal mesoderm. other vegetal cells on left (ventral vegetal cells), induce ventral mesoderm. S6-7 cortical rotation translocates dsh and wnt11 to dorsal mesoderm region , leading to stabilization/accumulation of b-cat. Nieuwkoop center is the only region that has both b-cat and vg1 (tgf-beta signal) S8 goosecoid expression is marker of dorsal mesoderm. Siamois gene (is a tf) has multiple b-catenin binding sites so when beta-cat is stabilized in region of future dorsal mesoderm, it binds to and activates transc of siamois. Siamois (tf) then binds to goosecoid gene ,, for trasnc activation of goosecoid (siamois not enuf) also need binding of tgf-beta signals ie vg1 ! So where have siamois and vg1 goosecoid exp(dorsal mesoderm gene) S9 nieuwkoop center: has both b-cat and veg1 . induces organizer gene such as goosecoid above it.