CHEM 180 Lecture Notes - Lecture 9: Birth Weight, Coronary Artery Disease, Atherosclerosis

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21 Jul 2016
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!"C?255284"contains"=8K52?9379>4>"that"when"cooked"&"chewed"(broken"down),"it"produces"sulphoraphane,"which"forms"
phase!2!enzymes"responsible"for"tying"up"foreign"chemicals"(potentially"toxic"materials,"including"carcinogens)"&"moving"
them"out"of"the"body"
!"increased"379@;bUb;>JLB;@"is"linked"with"82N;?&?9:;@&2E&59>5;?"
!"W?9@@459&Z5?K54E;?2K@&M;==4;[&57;B23?;M;>:42>"(an"animal"feeding"trial)"
" !"rats"fed"@K8372?9379>;"after"exposure"to"dimethyl"benzanthracene,"a"potent"carcinogen"found""in"smoke"
" !"70%"control"rats"developed"cancer"(twice"as"many"as"the"animals"fed"C?255284&;X:?95:)"
!"C?2552@3?2K:@"(young"sprouting"broccoli)"has"50"times"more"@K8372?9379>;"than"adult"broccoli"
!"W?9@@459&57;B23?;M;>:42>&Z9>&4>&M4:?2&@:KFL)"
" !"sulphorophane"added"to"cultured"human"cancer"cells"demonstrated"protection"against"cancer"
" !"indole!3!carbinal"in"cabbage"is"also"an"anti!carcinogen"
" !"people"who"eat"lots"of"fruits,"veggies,"and"spices"are"less"likely"to"have"cancer"!"an"association"
" !"maybe"because"they’re"consuming"less"meat"&"dairy"
Dr."Schwarz’s"Recommendations:"You"Are"What"You"Eat"
!"maintain"healthy"body"weight"
!"take"part"in"physical"activity"
!"cut"down"on"sugar,"salt,"processed"meat"
!"limit"red"meat"to"3"oz"
!"limit"alcohol"to"one"a"day"
!"limit"fat"to"30%"of"calories"
!"minimize"high"temp"cooking"
"!"use"spices"
!"eat"5!10"servings"of"fruits"&"veggies"a"day"
"
$;@@2>&U,&%4;:&<&);9?:&/&
!"Mark"Twain:"“Part"of"the"secret"of"success"in"life"is"to"eat"what"you"like"and"let"the"food"fight"it"out"inside”""
" !"Twain"was"puzzled"because"of"the"increased"nutritional"investigation"in"the"1800’s"&"conflicting"opinions"about"it"
!"SL8M;@:;?&G?979B"(of"Graham"cracker"fame)"was"telling"people"to"stay"away"from"meat"&"never"drink"water"with"a"meal"&"
to"eat"only"whole"grain"bread"
!")2?95;&'8;:57;?"known"as"“the"great"B9@:459:2?”"
" !"it"doesn’t"matter"what"you"eat,"as"long"as"you"chew"it"to"a"pulp"because"that"is"how"it’s"most"easily"digested"
!"m27>&)9?M;L&e;882=="(of"Kellogg"company)"was"strongly"9=94>@:&;9:4>=&B;9:"
!"m9B;@&S984@CK?L"suggested"that"health"lay"in"eating"a"S984@CK?L&@:;9`"
!"the"USDA"has"Choosemyplate.gov,"which"is"not"very"informative"
" !"they"do"recommend"a"lot"of"vegetables,"but"don’t"specify"what"the"protein"source"should"be"
!"the")9?M9?F&);98:7L&*9:4>=&O89:;"gives"more"detail"
" !"distinguishes"between"health"&"unhealthy"proteins"(processed"meats)"
" !"don’t"emphasize"dairy"production"
" !"recommend"polyunsaturated"oils"
!"some"promote"low"carb,"others"promote"vegan,"others"paleo,"others"promote"calorie"restriction"
!"calorie"restriction"can"extend"longevity"
!"in"1984,"eggs"&"bacon"seen"to"cause"high"cholesterol"
!"by"1999,"eggs"were"no"longer"seen"as"bad,"bc"studies"showed"that"an"egg"per"day"was"ok"
" !"some"say"that"you"don’t"need"to"lower"cholesterol"to"prevent"heart"disease,"and"others"say"you"do"
" !"lowering"cholesterol"by"diet"is"difficult"to"do"
!"I>5;8&e;L@,"an"American"physiologist,"made"the"8434F&7L32:7;@4@:"the"notion"that"heart"disease"is"linked"to"blood"
cholesterol"levels"&"that"cholesterol"levels"are"linked"to"saturated"fat"in"the"diet"
!"Keys"was"intrigued"by"previous"work:"
"1)""Nikali"Anichkov"fed"rabbits"cholesterol"&"it"led"to"buildup"in"arteries"of"animals,"which"triggered"heart"attacks"
" !"rabbits"normally"don’t"have"any"cholesterol"in"its"diet,"so"can’t"really"translate"to"humans"
"2)"John"Goffman"found"that"cholesterol"was"carried"in"bloodstream"mixed"with"protein"in"a"lipoprotein"complex""
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