CHEM 183 Lecture Notes - Lecture 1: John R. Brinkley, Serge Voronoff, Gastric Acid

• School: McGill University
• Department: Chemistry
• Course: CHEM 183
• Professor: David Noble Harpp

Document Summary

History: david and goliath, goliath was believed suffering from multiple endocrine neoplasia which is why he lost. John hunter (late 1700s: observed castrated roosters (removal of testicles), noticed the combs (red thing on top of their heads) shrink/collapsed, arnold berthold (mid 1800s, also castrated the roosters and returned the testicle in the body cavity. Rooster showed normal sexual behavior and comb development. Adrenal insufficiency aka addisson disease: suggesting that the adrenal gland must be releasing something that prevents these symptoms, dolanski (late 1800s) Interested in digestion; he knew pancreas and liver were releasing digestive juices when eating: proposed that the acidity decrease when eating and somehow this sends signals to the digestive juice to release. Injected acid in the rectum of the dog thinking it would be absorb in the blood stream and cause release of digestive juices; nothing happened lol.