CHEM 212 Lecture Notes - Lecture 4: Alkene, Azide, Molecularity
Document Summary
I. nucleophiles have the same attacking atom: basicity and nucleophilicity show the same trend. Nucleophiles have attacking atoms in the same period: basicity and nucleophilicity follow the same trend. The more electron rich the attacking atom the better the nucleophile. Polar aprotic solvents: effect on cation (counterion to the nucleophile) Polar aprotic solvents effect on cation (counterion to the nucleophile) Nucleophilicity increases down the group in most cases. Nucleophilicity increases down the group in most cases (a) negatively charged nucleophile, protic solvent (nucleophilicity increases down the group) Nucleophilicity increases down the group in most cases (b) neutral nucleophile, any solvent (nucleophilicity increases down the group) Nucleophiles have attacking atom in the same group: Nucleophilicity increases down the group in most cases (b) negatively charged nucleophile, aprotic solvent (exception: nucleophilicity decreases down the group) Does not depend on concentration of nucleophile, works with poor nucleophiles.
