ANAT 322 Lecture Notes - Lecture 15: Arcuate Nucleus, Placenta, Kiss1-Derived Peptide Receptor
3 Sep 2016
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Give t develop secondary sex characteristics; can be continuous, don"t need pulse. Can"t give gnrh because pituitary still wouldn"t make lh. After 2 weeks: fsh normalizes (suggests that fsh related to feedback regulation), t within normal range. Even though circulating t normal, intratesticular t levels still low. Stimulate local t: give lh analog (hcg, pregnancy hormone), on same receptor but longer half- life stimulate t in testes testes grow. After 2 years: oligozoospermic (low sperm count), conceived child w/mutation for lhb gene. Need high intra-testicular testerosterone to stimulate spermatogenesis (lh dependent) Spermatogenesis starts as hormone-independent (like follicle in females), then t-dependent. Outside of tubule: spermatogonial stem cells, divide to make copies & progeny. Early stages independent of hormone, later stages of spermatogenesis require t hormone support. Male: need wait at least 2 months to reach azoospermic because spermatogenesis 64 days. Kiss pulse in arc directly regulate gnrh pulse lh & fsh pulse make t & inhibin b.
