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Lecture

Regulation of RNA Splicing.docx

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Department
Biology (Sci)
Course
BIOL 200
Professor
Monique Zetka
Semester
Fall

Description
October 4, 2013 BIOL-200 DNAsequence rich has a Poly (A) signal rich inAU repeats does not get transcribed PolyAsignal (GU signal) if mutated, doesn't work CPSF binds first on theAAUAAAsequence CStF binds to G/U region -sequences are conserved, if mutated RNAcannot be processed -conserve and protect RNAfrom endonucleases and mark it as an RNA major step between binding complexes to sequence: is the recruitment of PAP which extends repeats -PAP has to bind betweenAAUAAAand G/U before it can cleave -linking recruitment factors and cleaving for enzymatic activity PAP adds Poly(A) really slowly, cleaves RNAat 3' end PABPII can recognize the twelveArepeats and binds to it so that it stimulates PAP at a high efficiency -elongation of poly A tail and at a faster rate, as well as when to stop adding A residues (polyadenylation) make exons “work” for you, there are sequences w/in exons that can recruit factors that will tell splicing enzymes where to go > exon-intron splicing boundary Regulation of splicing of specific pre-mRNAs can increase genetic diversity Alternative splicing controls sex determination in Flies -sexually dimorphic characteristics have to be regulated -Sxl
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