BIOC 212 Lecture Notes - Lecture 12: Electrochemical Gradient, Atp Hydrolysis, Secretion
14 Apr 2018
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Document Summary
Srp-ribosome complex during translation: translocation at the er is required to be co- translational. Tail anchored proteins alternative targeting pathway: tail anchor: tm helix at c-terminus is the targeting signal. Tail anchor targeting: trc40/get3 atpase homodimer of 40kda subunits, nucleotide-free state receives ta from bat3, atp-bounds state is closed around the ta, then docks onto integral membrane receptor. Get1/2 on er: atp hydrolysis releases ta protein into membrane, then adp release dissociates trc40 from get1/2, does not use sec61 translocon. Inner membrane (im): oxidative respiration, atp synthesis; metabolite transport: double-membrane organelle each compartment has distinct functions and contents, matrix: citric acid cycle, fatty acid and other metabolism, om is permeable to small molecules through pores, but not. Intermembrane space (ims) and outer membrane (om): apoptosis control folded proteins. Membrane potential: respiration drives the transfer of protons from matrix to ims, the proton gradient drives the generation of.
