BIOC 311 Lecture 20: Fatty Acid Synthase
15 Dec 2015
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Document Summary
Irreversible step, most important regulation point for fa synthesis. Glucagon, adrenaline (epinephrine) activates camp-dependent kinase (pka) leading to inactivation of acc. Insulin stimulates dephosphorylation (via protein phosphatase) of acc, leading to activation of. Amp kinase acts as a fuel gauge to regulate acc. Product of acc also a regulator: malonyl-coa inhibits transport of fatty acyl-coa into the mitochondria to be broken down. Mammalian fas is a dimer with two multi-reaction chambers. Acp carries the intermediates to different active sites to get the fatty acid made up bigger and bigger. Multiple steps to elongate the fatty acid. Crystal structure of what fatty acid looks like: Acp is modified so it can covalently transport substrates. There is an a (left) and a ppe (right) Acp domain has a serine on it that will pick up the ppe arm by binding to the phosphate. Acp acts as a robotic arm that goes into the active site.
