BIOC 311 Lecture Notes - Lecture 35: Leptin, Ob River, Neuropeptide Y

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The physiological systems that help maintain body weight constant. In 1950, kennedy et al. proposed the existence of a circulating signal generated in proportion to body fat stores that is able to influence appetite and energy expenditure in a coordinated manner to regulate body weight. In a 1950 discovery of a recessive mutant mouse associated with massive obesity. The defective gene in these mice was named obese and these mice are referred to as ob/ob. Another recessively inherited form of obesity was discovered, and the mice were called diabetes and the gene is referred to as db/db mouse. Parabiosis: is the surgical union of two animals that leads to development of a common circulation. Outcome of parabiotic unions of ob/ob mutants with normal lean littermates (+/+: the wt mice have a circulating factor that is missing in ob mice. Outcome of parabiotic unions of db/db mutants with ob/ob mutants.

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