BIOC 311 Lecture Notes - Lecture 31: Threonine, Homocysteine, Cystathionine

• School: McGill University
• Department: Biochemistry
• Course: BIOC 311
• Professor: Julie St- Pierre

Document Summary

Lecture 31: aa as carbon sources mercredi 18 novembre 2015. Cps1: requires nag, which is activated by nags (arginine and glutamine) Long term regulation: coordinated transcription control and total protein level of set of enzymes. 2 major routes: reduced intake of proteins or. Stimulating pathways of nh4 excretion: (1) phenylbutyrate: final product is non toxic which can be secreted in urine. Every phenylbyturate metabolized, it involves one molecule of glutamine which has 2 molecules of ammonium. Recall that glutamine synthetase is activated by a-kga (comes from cac or from oxidative deamination of glutamate) (2) benzoate: final product is non toxic and can be excreted into urine. One molecule of glycine is consumed, which its synthesis requires one molecule of ammonium. If patient undergoes diseases, ammonium levels may increase in a way those fatty acids are insufficient to remove excess ammonium. Remaining carbon skeletons can be degraded for energy (intermediates that feed into.