INDS 211 Lecture Notes - Lecture 35: High-Protein Diet, Bone Resorption, Rankl

• School: McGill University
• Department: Interndisciplinary Studies
• Course: INDS 211
• Professor: Bill Buckett

Document Summary

Hormone replacement therapy: age-related hormone changes, women"s hormone changes are much more dramatic compared to men, corresponding to women"s menopause. As a consequence of decrease e, there is an increase in gonadotropins: sources of e: before menopause, ovary is predominant producer. After menopause, adrenal gland and fat tissue take over production: targets of e action: brain, heart, liver, breast, uterus, bone. Impact of e deficiency: headaches and hotflashes, risk cvd, skin and mucous membrane dryness/change in texture, vaginal dryness/itching, loss of bone mass: time course of menopause-related symptoms, early (weeks-months): hot flashes, insomnia, moodiness, late (years-decades): osteoporosis, cvd. Intermediate (months-years): vaginal atresia, bladder dysfunction, skin atrophy. Early menopause-related symptoms: hot flashes, night sweats, moodiness: 50-85% of postmenopausal women, tx: lifestyle modifications, hormone therapy, non-hormonal approaches. **hrt relieves menopausal symptoms/physical changes associated with depleted endogenous e i. e. osteoporosis, cvd, stroke; thromboembolism, colon ca, cognitive impairment/dementia, breast ca. Opg bone formation: post-menopausal ( e) - rankl osteoclast activity bone resorption.