MIMM 211 Lecture Notes - Lecture 26: Aspergillus Oryzae, Tolypocladium Inflatum, Leucocoprinus
Document Summary
Napoleo(cid:374)"s death: montreal moment: ben weeder loved nappy. Not the british, (cid:271)ut gosio"s disease: (cid:272)heele"s gree(cid:374) (cid:449)allpaper pig(cid:373)e(cid:374)t (cid:272)o(cid:374)tai(cid:374)ed arse(cid:374)i(cid:272), bread mold grows on walls and ate the wallpaper and released arsenic gas, nappy breathed it in. Second ary met abolites: ability of fungi to pu mp out t hings to modi fy it s enviro nme nt. Ex. pharmaceuticals: antibiotics, though some bacteria make some now too. Aminoglycosides all end in mycin, so fungal origin. Polyene was originally isolated from fungi too. Someone shot iceman utzi in the back with an arrow when he was running from italy to austria, he had stuff i(cid:374) his pou(cid:272)h, i(cid:374)(cid:272)l bir(cid:272)h pol(cid:455)pore fu(cid:374)gus stru(cid:374)g o(cid:374) sti(cid:272)ks. He"d (cid:271)ee(cid:374) eati(cid:374)g it as a (cid:374)atural la(cid:454)ati(cid:448)e and antibiotics against whipworm. He was infected by whipworm gi bleeding, anemia. Transgenic products from s. cerevisiae powerhouse: hydrocortisone, hep b vaccine, hpv vaccines. Cordyceps also infects caterpillars: used traditional asian medicine in powder form, super expensive.