MIMM 214 Lecture Notes - Lecture 7: Nf-Κb, Gene Expression, Ubiquitin
7 Jun 2018
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Lecture 6 – January 18, 2017
Innate immune recognition
- Pathogens have specific molecular patterns that support their life style = pathogen associated
molecular patterns (PAMP)
- PAMPs are recognized by pattern recognition receptors (PRR) on host cells
PAMPs
- Molecules found on microbe surface
o Peptidoglycan (PGN) and OGN-embedded molecules (LTA) on the cell wall of gram-
positive bacteria
o Endotoxin (LPS) on the cell wall of gram negative bacteria
o Flagellin on bacteria with flagella
- Nucleic acid patterns
o dsRNA in viruses
o ssRNA in viruses
o unmethylated CpG in bacteria and herpesviruses
- others
- these are common pattern expressed by many microorganisms. Not specific to a give pathogen
PRRs
- receptors in host cell that recognize PAMPs
- Located at different sites depending on the PAMP they recognize
o Cell surface
o Intracellular
o Secreted
- Several groups
o Toll like receptors (TLR)
o NOD like receptors (NLR)
o RIG like receptors (RLR)
o C-type lectin receptors (CLR)
o Ficolins
o Others
- Signaling pathways are activated, contributing to innate/inflammatory responses
General features of signal transduction
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