MIMM 214 Lecture Notes - Lecture 22: Tumor Necrosis Factor Alpha, B Cell, Interferon Gamma
7 Jun 2018
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Lecture 22 – February 24, 2017
TH17
Th17 cells
- In response to TGF-beta, IL-6 and IL-23 (signal 3)
- Characterized by production of IL-17 (effector cytokine)
- Master transcriptional factor: RORgammaT
- Discovered in 2005
o Following a discovery in 2003 that IL-23 is important for development of autoimmunity
o Rethinking of classic Th1 vs Th2 paradigm
o Very active research
- Enhances neutrophil responses and mucosal immunity
o Helps respond to extracellular bacteria and fungi
- Pro-inflammatory response & involved in many autoimmune disorders
- Th17 cells are a relatively new discovery
- This is meant to illustrate the scientific process and that much remains unknown
- Secrete IL-17 and IL-22 → stimulates other cells to secrete more cytokines and antimicrobial
peptides
- Recruits neutrophils
- To aid in targeting extracellular bacteria and fungi
Th17 and inflammation
- IL-17 is a pro-inflammatory cytokine
- Th17 responses are involved in a number of inflammatory diseases, including autoimmune
diseases and allergies
o Psoriasis
o IBD
o Asthma
o Rheumatoid arthritis
o MS
find more resources at oneclass.com
find more resources at oneclass.com
Document Summary
In response to tgf-beta, il-6 and il-23 (signal 3) Characterized by production of il-17 (effector cytokine) Discovered in 2005: following a discovery in 2003 that il-23 is important for development of autoimmunity, rethinking of classic th1 vs th2 paradigm, very active research. Enhances neutrophil responses and mucosal immunity: helps respond to extracellular bacteria and fungi. Pro-inflammatory response & involved in many autoimmune disorders. This is meant to illustrate the scientific process and that much remains unknown. Secrete il-17 and il-22 stimulates other cells to secrete more cytokines and antimicrobial peptides. To aid in targeting extracellular bacteria and fungi. Th17 responses are involved in a number of inflammatory diseases, including autoimmune diseases and allergies: psoriasis. Therapies targeting il-17 are currently being studied and some have already been approved for clinical use. Il-17 and il-22 induce epithelial cells to produce antimicrobial peptides: can contribute to killing/slowing bacteria, the th17 cells will travel to infection.
