MIMM 214 Lecture Notes - Lecture 8: Chemokine Receptor, Cytokine Receptor, Interleukin-4 Receptor
5 Jan 2019
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Made bigger if injected to prevent secreting it in urine. Affect the behaviour (development, growth, differentiation) of: One cytokine may be produced by many different cell types, and have effects on many different cell types (pleiotropism) Different cytokines may have the same effect (redundancy) Mostly soluble, some have membrane-bound forms (i. e. tnf) They are not antigen-specific: produced in immune responses no matter what the ag are (non-allelic same in same species) No unique gene cluster (spread out on chromosomes) Cytokine production is tightly regulated at 2 levels: Post-transcriptionally: rna stability regulated by 3" au rich region (rapidly degraded or stay for a while) Interleukins (il): from 1 to 37 so far! (most common) Interferons (ifn): type i (ifn- , ) and type ii (ifn- ) Tumor necrosis factors (tnf): and (lymphotoxin) Hematopieotins or growth factors: e. g. , gm-csf, g-csf. Chemokines: e. g. mip-1a and mip-1 , rantes, il-8 and many more. Note: give cancer patients growth factors g-csf (granulocytes) because they are immunosuppressed.
