MIMM 387 Lecture Notes - Lecture 5: Human Genome Project, Pharmaceutical Drug, Amgen
26 Apr 2019
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The biggest surprise from mapping the genome, was that very little was actually encoding genes. There are only 20,000 genes in the genome = 2% of total genome. The rest is micro rna / regulatory elements. 2001 draft sequence: was pretty crude, missing 150,000 gaps. 2007: venter worked with someone at u of t to map the full diploid genome. What happened in the 15x years after the human genome project: We still don"t even have an algorithm that can compare 2x human genomes. So its very hard to turn the basic science, into something clinically useful. 2013: venter launched human longevity, with the goal to sequence 1 mill human genomes by: right now, he is trying to develop the algorithm that will compare genomes and obtain information from it. This is going to be very hard project. 2016: google tried to do a small experiment with 1000 genes.
