NEUR 310 Lecture Notes - Lecture 10: Visual Cortex, Brain-Derived Neurotrophic Factor, David H. Hubel
4 May 2015
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Generally an activity dependent process that can continue into adult life in some regions of the adult mammalian brain. (hippocampus as well as) Provides a way to ensure that all axons capture an appropriate cells. (by having more sysnappses and then tuning away their nummber) number of target. Retinal ganglion cells (rgcs) project axons to: lateral geniculate nucleus (lgn); main pre cortical terminus for input to the visual cortex, superior colliculus; control of saccadic eye movements. Main relay for rgc projections. In primates, including humans, the lgn contains six layers of neurons. One type of experiment: labeling of the post synaptic neurons. Inject inside the eyes, the radio labeled acid which will be integrated into the to protein made by that eye, and they will get the lgn. Cells with similar eye preference were. 1960s; electrophysiological two different eyes stimulated grouped in columns. Classic experiment by hubel and wiesel demonstrated experience dependence of ocular dominance columns and critical period.
