NUR1 420 Lecture Notes - Neomycin, Azithromycin, Mycoplasma Pneumonia
7 Sep 2013
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Document Summary
Once a culture and sensitivity is complete, a narrow-spectrum/bacteria specific drug can be used. Antagonism: combination of 2 antibiotics that actually decrease the drug"s efficacy. Multiple drugs therapy has potential to promote resistance. Superinfections: occurs when micro-organisms that are normally present in the body are destroyed. this flora serves purpose such as producing antibacterial substances and competing with pathogenic organisms for space and nutrients. Symptoms of superinfections include diarrhea, bladder pain, painful urination and abnormal vaginal discharge. Broad spectrum antibiotics are more likely to cause superinfections. Became a miracle drug preventing thousands of deaths. Indicated in the treatment of: pneumonia, meningitis, skin bone and joint infections, stomach infections, blood and heart valve infections, gas gangrene, tetanus, anthrax, cicle cell anemia in infants. Works by disrupting call walls, causing them to break down. Human cells do not have cell wall thus action specific to bacteria. Some bacteria develop resistance by secreting an enzyme called beta lactamase or penicillinase.
