PHAR 300 Lecture Notes - Lecture 3: Drug Action, Partial Agonist, Indirect Agonist

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Magnitude of drug effect: methods of quantification and comparison from the curve and compare them. Potency of the drug = where the curve lies few people respond and the more you increase, the more people will respond. Super sensitive responders (low dose) to super difficult responders (high dose). S-shaped curve: biological variation at what level the drug has an effect by increasing doses and asking yes/no per increase if there"s an effect. Low dose : dose response curve compare different drugs. Extract certain #s: receptor occupancy doesn"t need to occupy every receptor to get. Partial agonist- you don"t fully activate the receptor. On single individual (compare two drugs in same person). On groups of people: drugs differ in affinity for receptor binding site, drugs differ in ability to activate receptor (efficacy) Affinity (ability to bind) vs efficacy (ability to activate) Little to no s. e. response from the drug.