PHAR 300 Lecture Notes - Lecture 3: Therapeutic Index, Lethal Dose, Active Transport
8 Dec 2017
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Number responding: the drug is given at incremental doses to 100 people. The dosage that causes an effect on each individual is then recorded and plotted: fig. 1 shows a normal distribution: at low dosage, very few people respond supersensitive, as dosage progressively increases, more people respond. Most people respond in the middle: some individuals are super-resistant responders need higher dosage, cumulative percentage response. Cumulative % responding: out of the population, the maximum percentage of people who can respond is 100%. Record the percentage of people responded when dose is increased: fig. 2 is a semi-logarithmic plot (s shaped curve), with a straight-line slope in middle: can obtain numerical information, such as the concentration of drug when 50% of the population responds to the drug = effective dose (ed50). This number can then be compared with other drugs: this curve is called dose response curve, dose is the independent variable.
