PHAR 300 Lecture Notes - Lecture 3: Local Anesthetic, Ataxia, Biological System

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Tutorials start next week on mondays at 5 and fridays at noon. Saturday is the limit to apply as a phar 300 ntc. Today"s lecture is based on chapter 3 of the textbook. Magnitude of drug effects: methods of quantification and comparison. Use a statistical approach: plot all-or-none responses, biological system will naturally tend to form a normal distribution. You get a range minimum dose to see effect, maximum dose at which everyone feels the effect. You also know the mean dose, and the range in which the majority responds: cumulative (s curves) graph: the percentage of population which have responded by a certain dose. Plot on a log scale gives a straight line in the centre: this creates a dose-response curve. The ed50 (effective dose) is the dose required to produce a therapeutic effect in 50% of the population.