PHAR 300 Lecture 14: Lecture 14
10 Jan 2019
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Document Summary
Metabolism of testosterone into: dihydrotestosterone, estrogen. Process: mutations in androgen receptors: don"t have full response, testosterone/dihydro binds to receptor, cell responds, turns on reception of androgen recponse, can be metabolized to dht, other proteins. More than one way of interacting with receptor. You can be making the other stuff based on other tissues. Testosterone i s a major messenger from which you can also make other tuff can be tissue-specific. One of the ways of stimulating hair growth is decrease increase of dihydrotestosterone. You need different products of the process in different tissues. Sex drive: androgens, not estrogens: remove aggression with removal of testosterone, decreased eating. Mcgill university phar 300 prof. e. zorchyta, prof. b. hales: hypothalamus produces gnrh. Hormonal: injections, implants, cream (give to make negative feedback to shut off local synthesis of testosterone without losing secondary characteristics) list the analogue: testosterone, testosterone and progestin.
