PHAR 300 Lecture Notes - Lecture 15: Seminiferous Tubule, Sertoli Cell, Leydig Cell

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Sperm produced in the testis then goes into the epididymis. In the male, gnrh is released from the hypothalamus and triggers the pituitary to release lh and. Lh from the pituitary targets leydig cells which will release testosterone to the sertoli cells. Fsh from the pituitary gland supports sertoli cells which then support the production and maturation of sperm. Leydig cells are outside the seminiferous tubule and produce high local testosterone. The testosterone that they make can move across membranes to get to the sertoli cells. Adult men produce 5-7 mg of testosterone daily. 5-alpha reductase converts testosterone to dihydrotestosterone (dht) Estradiol can also be made from testosterone. Human androgen receptor gene: structural organization and protein. Testosterone will migrate through blood stream bound to proteins since it is lipophilic. Dht can also interact with the receptors. Testosterone and estradiol feedback and inhibit the release of lh from the pituitary and gnrh from the hypothalamus.