PHAR 300 Lecture 11: Aspirin and Other NSAIDs
27 Oct 2015
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Oct. 13, 2015: nsaids usually taken chronically, possibilities for problems are not as severe as steroidal anti-inflammatory drugs, a lot of them are restricted to prescription medication, common nsaids are: salicylates and non-salicylates. Hoffman was a chemist who played around with the chemical structure of salicin. He made an acetyl derivative of it and tested it on animals. In 1971, john vane, a scientist, found out what aspirin does. Oct. 13, 2015: prostaglandins can cause inflammation and pain, and also act to protect the gastrointestinal tract, thromboxane is important for platelet aggregation to stop bleeding, inflammation and pain are useful up to a point. It"s a dimer embedded in the endoplasmic reticulum o: aa enters into the active site of the enzyme, and the enzyme then forms the ring. + adds oxygen then releases the compound: can end up with a variety of different prostaglandins, can also get thromboxane a2, nsaids block the cyclooxygenase that makes the prostaglandins.
