PHAR 300 Lecture Notes - Lecture 22: Drug Interaction, Intestinal Epithelium, Carbamazepine

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 300
• Professor: Edith Zorychta

Document Summary

Patients often receive >20 drugs in hospitals. Drug interactions compound with each additional drug taken. The very young and the very old have a different capacity to metabolize drugs. There is a big problem with herbal remedies interacting with other drugs. On all prescription medications or over-the-counter medications, there will be indications for drug. Information for consumers about drugs are widely available interactions on the package. There are many interaction risks with ethanol. Food is full of chemicals so there is the possibility of drug interactions with food as well. Adverse effects of drug interactions occur when all of these fail: Patient factors: genetics, diseases, diet/nutrition, environment, smoking, alcohol. Drug administration: dose, duration, dosing times, sequence. Clinical outcome of drug interactions has a high variability: this makes it harder to document. Results can be: additive (1+1=2, synergistic (1+1=3, potentiated (1+0=2, antagonistic (1+1=0. 5) Pharmacodynamic: modulate a drug"s effect at a given plasma concentration.