PHAR 301 Lecture 4: PHAR 301 - lecture 4
12 Feb 2017
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Phar 301 lecture 4: clarke (short notes) **drugs to know by name: sinemet (l-dopa + carbidopa), deprenyl (selegiline) James parkinson was a family doctor and scholar who noticed certain sxs in 6 pts new disease = shaking palsy . Hitler suspected of having pd his doctor gave him many medications over the years which may have induced pd sxs, mohammed ali developed pd from recurrent tbi. Environmental factors: strong correlation between incidence of pd and pesticide use (montreal study) but remember that correlation causation! Nothing has been shown to definitively cause pd in the population as a whole. Da neurons die in pd which accounts for the observed sxs. Nigrostriatal daergic pw in the brain: cell bodies in the midbrain (substantia nigra) project to forebrain region (striatum aka caudate putamen) Striatum = part of the basal ganglia, receives input from neocortex, sensory info is converted to motor output and.
