PHAR 301 Lecture 6: PHAR 301 - lecture 6

• School: McGill University
• Department: Pharmacology and Therapeutics
• Course: PHAR 301
• Professor: Barbara Hales

Document Summary

Phar 301 lecture 6: bowie (short notes) Myocardial ischemia: imbalance in the blood supply to the heart. Major drug groups: symptomatic: nitrates, ca channel blockers (work at level of coronary circulation), beta blockers (antagonise effect of. Statins: inhibit cholesterol synth by inhibiting hmg-coa reductase. Niacin decreased vldl secretion (high levels of vldl associated with coronary disease) Fibrates lpl synthesis: help to degrade vldl (different from niacin: anti-coagulants prevent blood from clotting easily, good for ppl with narrow vessels, dangerous in surgery. Heparin binds to enzyme inhibitor antithrombin iii (at iii), activation leads to inactivation of factor xa and other proteases: fibrinolytic used to break up clots, especially helpful in treating emboli preventing strokes or pulmonary ht. Tissue plasminogen activators - endogenous: anti-platelet prevents aggregation of platelets. Plaque formation: blood vessel damage plaque formation (inflammation) 1) endothelium smooth muscle interface plaque or 2) ruptured lesion in endothelium narrowing of blood vessel lumen.