PHAR 301 Lecture Notes - Lecture 10: Decongestant, Rhinitis, Allergic Rhinitis
13 Feb 2016
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Rhinitis = inflammation of nasal mucous membrane (mucosa) o o. Ejaculation is accompanied by an increase of sympathetic drive. You would think that you"d be able to conduct enough sympathetic drive to unclog your nose by vasoconstriction. Alpha1 and alpha2 receptors are located on the blood vessels in the mucosa of the nose o. They are activated by adrenaline or noradrenaline which cause vasoconstriction (because when you have a cold you have vasodilation) o. You want to stimulate those receptors in order to counter the vasodilation. Chapter 11 - drugs affecting the sympathetic nervous system. Chapter 14 - histamine and antihistamines o o. Vasodilation makes the nasal cavity smaller, vasoconstriction alleviates this. The mucosa in the nose is a form of erectile tissue o. The tissue lining nasal cavity fills with blood and. It can only expand inwards expands which causes congestion. Sympathomimetic drugs - increase or mimic (nor)adrenergic transmission.
